| Titre : |
The chemical biology of DNA damage |
| Type de document : |
texte imprimé |
| Auteurs : |
Nicholas E Geacintov, Éditeur scientifique ; Suse Broyde, Éditeur scientifique |
| Editeur : |
Weinheim : Wiley-vch Verlag |
| Année de publication : |
2010 |
| Importance : |
XXII, 449 p. |
| Présentation : |
ill. |
| Format : |
25 cm |
| ISBN/ISSN/EAN : |
978-3-527-32295-4 |
| Note générale : |
Bibliogr.p. 429-437. - Index |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Altération de l'ADN
DNA damage
DNA -- Chemical biology |
| Index. décimale : |
577.213.3 Synthése enzymatique in vitro de l'ADN, de l'ARN. Systèmes de la polymérie de l'ADN, de la réplication de l'ARN. |
| Résumé : |
Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, part I focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account transcription machineries.
A ready reference for bio chemists, toxicologists molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health. |
| Note de contenu : |
Au sommaire:
1. Introduction and perspectives on the chemistry and biology of DNA damage
2. Chemistry of inflammation and DNA damage: biological impact of reactive nitrogen species
3. Oxidatively generated damage to isolated and cellular DNA
4. Role of free radical reactions in the formation of DNA damage
5. DNA damage caused by endogenously generated products of oxidative stress
6. Polycylic aromatic hydrocarbons: multiple metabolic pathways and the DNA lesions formed |
The chemical biology of DNA damage [texte imprimé] / Nicholas E Geacintov, Éditeur scientifique ; Suse Broyde, Éditeur scientifique . - Weinheim : Wiley-vch Verlag, 2010 . - XXII, 449 p. : ill. ; 25 cm. ISBN : 978-3-527-32295-4 Bibliogr.p. 429-437. - Index Langues : Anglais ( eng)
| Mots-clés : |
Altération de l'ADN
DNA damage
DNA -- Chemical biology |
| Index. décimale : |
577.213.3 Synthése enzymatique in vitro de l'ADN, de l'ARN. Systèmes de la polymérie de l'ADN, de la réplication de l'ARN. |
| Résumé : |
Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, part I focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account transcription machineries.
A ready reference for bio chemists, toxicologists molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health. |
| Note de contenu : |
Au sommaire:
1. Introduction and perspectives on the chemistry and biology of DNA damage
2. Chemistry of inflammation and DNA damage: biological impact of reactive nitrogen species
3. Oxidatively generated damage to isolated and cellular DNA
4. Role of free radical reactions in the formation of DNA damage
5. DNA damage caused by endogenously generated products of oxidative stress
6. Polycylic aromatic hydrocarbons: multiple metabolic pathways and the DNA lesions formed |
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577 Propriétés générales de la matière vivante. Bases matérielles de la vie. Biochimie. Biologie moléculaire. Biophysique
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