| Titre : | Computational toxicology : risk assessment for pharmaceutical and environmental chemicals |
| Auteurs : | Sean Ekins, Éditeur scientifique |
| Type de document : | texte imprimé |
| Editeur : | New York : John Wiley & Sons, 2007 |
| ISBN/ISSN/EAN : | 978-0-470-04962-4 |
| Format : | XXII, 814 p. / ill. / 24 cm |
| Note générale : | Bibliogr. p.772-775. - Index |
| Langues : | Anglais |
| Index. décimale : | 615.9 (Toxicologie en général. Etude des produits toxiques et des poisons. Intoxication) |
| Tags : | Toxicologie -- Modèles mathématiques Toxicologie -- Simulation par ordinateur QSAR (biochimie) Toxicology -- Mathematical models Toxicology -- Computer simulation QSAR (Biochemistry) Toxicology -- Methods Computer simulation Drug toxicity Environmental pollutants -- Toxicity Risk assessment |
| Résumé : |
This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with:
*An introduction to toxicology methods and an explanation of computational methods *In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels *Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena *Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development. |
| Note de contenu : |
Summary of the book:
1. Introduction to toxicology 2. Computational methods 3. Applying computers to toxicology assessment: pharmaceutical 4. Applying computers to toxicology assessment: environmental 5. New technologies for toxicology, future and regulatory perspectives |
Exemplaires (1)
| Cote | Support | Localisation | Section | Disponibilité | Etat_Exemplaire |
|---|---|---|---|---|---|
| 615.9 COM | Papier | Bibliothèque Centrale | Génie Chimique | Disponible | Consultation sur place |
