| Titre : | Preparation of compounds labeled with tritium and carbon-14 |
| Auteurs : | Rolf Voges, Auteur ; J. Richard Heys, Auteur ; Thomas Moenius, Auteur |
| Type de document : | texte imprimé |
| Editeur : | New York : John Wiley & Sons, 2009 |
| ISBN/ISSN/EAN : | 978-0-470-51607-2 |
| Format : | XVI, 664 p. / ill. / 25 cm |
| Note générale : | Bibliogr.p.634-637. -Index |
| Langues : | Anglais |
| Index. décimale : | 66.09 (Réactions chimiques. Procédés chimiques et biochimiques particuliers) |
| Tags : | Composés organiques -- Synthèse Sciences de la santé Tritium Carbone -- Isotopes |
| Résumé : |
Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals.
Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: * Formulation of synthetic strategies for preparing labeled compounds * Isotope exchange methods and synthetic alternatives for preparing tritiated compounds * In-depth discussion of carbon-14 building blocks and their utility in synthesis * Preparation of enantiomerically pure isotopically labeled compounds * Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium. |
| Note de contenu : |
Au sommaire:
1. Introduction 2. Strategies for Target Preparation 3. Preparation of Tritium-Labeled Compounds by Isotope Exchange Reactions 4. Preparation of Tritium-Labeled Compounds by Chemical Synthesis 5. Barium [14C]Carbonate and the Preparation of Carbon-14-Labeled Compounds via One-Carbon Building Blocks of the [14C]Carbon Dioxide Tree 6. Preparation of Carbon-14-Labeled Compounds via Multi-Carbon Building Blocks of the [14C]Carbon Dioxide Tree 7. Preparation of Carbon-14-Labeled Compounds via the [14C]Cyanide Tree 8. Preparation of Carbon-14-Labeled Compounds via the [14C2]Acetylene Tree 9. Preparation of Carbon-14-Labeled Compounds via the [14C]Cyanamide Tree 10. Reconstitution Strategies 11. Preparation of Enantiomerically Pure Compounds Labeled with Isotopes of Hydrogen and Carbon 12. Biotransformations in the Preparation of Compounds Labeled with Carbon and Hydrogen Isotopes |
Exemplaires (1)
| Cote | Support | Localisation | Section | Disponibilité | Etat_Exemplaire |
|---|---|---|---|---|---|
| 66.09 VOG | Papier | Bibliothèque Centrale | Génie Chimique | Disponible | En bon état |
