| Titre : |
Metallopharmaceuticals I : DNA interactions |
| Type de document : |
texte imprimé |
| Auteurs : |
Clarke , M. J., Éditeur scientifique ; Sadler , P. J., Éditeur scientifique |
| Editeur : |
Berlin ; London ; Cham : Springer |
| Année de publication : |
1999 |
| Collection : |
Topics in biological inorganic chemistry, ISSN 1437-7993 num. Vol. 1 |
| Importance : |
199 p. |
| Présentation : |
ill. |
| Format : |
24 cm |
| ISBN/ISSN/EAN : |
978-3-540-64889-5 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Chimie inorganique
Médicaments
Platine -- Composés -- Emploi en thérapeutique
Ruthénium -- Composés -- Emploi en thérapeutique
ADN
Cancer -- Chimiothérapie |
| Index. décimale : |
577.1 Bases chimiques de la vie. Biochimie et chimie bioorganique en général |
| Résumé : |
Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonance imaging (e.g.GD)demonstrates that the toxicity of metals can be finaly controlled via the appropriate choice of ligands. The successful trageting of radiosotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics. |
| Note de contenu : |
Contents:
- Anticancer activity of cisplatin and related complexes.
- Development of an orally active platinum anticancer drug: JM216.
- Trans-platinum compounds in cancr therapy.
- Chemistry and biology of multifunctional DNA binding agents.
- Role of metal ions in antisense and antigene stategies.
- Sulfoxide ruthenium complexes.
- Non-platinum antitumor compounds. |
Metallopharmaceuticals I : DNA interactions [texte imprimé] / Clarke , M. J., Éditeur scientifique ; Sadler , P. J., Éditeur scientifique . - Berlin ; London ; Cham : Springer, 1999 . - 199 p. : ill. ; 24 cm. - ( Topics in biological inorganic chemistry, ISSN 1437-7993; Vol. 1) . ISBN : 978-3-540-64889-5 Langues : Anglais ( eng)
| Mots-clés : |
Chimie inorganique
Médicaments
Platine -- Composés -- Emploi en thérapeutique
Ruthénium -- Composés -- Emploi en thérapeutique
ADN
Cancer -- Chimiothérapie |
| Index. décimale : |
577.1 Bases chimiques de la vie. Biochimie et chimie bioorganique en général |
| Résumé : |
Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonance imaging (e.g.GD)demonstrates that the toxicity of metals can be finaly controlled via the appropriate choice of ligands. The successful trageting of radiosotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics. |
| Note de contenu : |
Contents:
- Anticancer activity of cisplatin and related complexes.
- Development of an orally active platinum anticancer drug: JM216.
- Trans-platinum compounds in cancr therapy.
- Chemistry and biology of multifunctional DNA binding agents.
- Role of metal ions in antisense and antigene stategies.
- Sulfoxide ruthenium complexes.
- Non-platinum antitumor compounds. |
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