| Titre : | Quantitative modeling in toxicology |
| Auteurs : | Krishnan, Kannan, Éditeur scientifique ; Andersen, Melvin E., Éditeur scientifique |
| Type de document : | texte imprimé |
| Editeur : | New York : John Wiley & Sons, 2010 |
| ISBN/ISSN/EAN : | 978-0-470-99809-0 |
| Format : | XVII, 485 p. / ill. / 25 cm |
| Note générale : | Références bibliogr. - Index |
| Langues : | Anglais |
| Index. décimale : | 615.9 (Toxicologie en général. Etude des produits toxiques et des poisons. Intoxication) |
| Tags : | Toxicologie -- Modèles mathématiques Toxicology -- Mathematical models Toxicology -- methods Environmental Exposure -- adverse effects Hazardous Substances -- toxicity Models, Biological Toxicity Tests -- methods |
| Résumé : | "In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. Each chapter describes the mathematical foundation, parameter estimation, challenges and perspectives for development, along with the presentation of a modeling template. Additionally, tools and approaches for conducting uncertainty, sensitivity and variability analyses in these models are described" |
| Note de contenu : |
Summary :
Chapter 1. Quantitative modeling in toxicology: An introduction Chapter 2. PBPK modeling: a primer Chapter 3. Pharmacokinetic modeling with Manganese - An essential element Chapter 4. Physiologically-based modeling of pharmacokinetic interactions in chemical mixtures Chapter 5. Physiological Parameters and Databases for PBPK Modeling Chapter 6. Modeling cholinesterase Inhibition Chapter 7. Modeling of Protein Induction and dose-dependent hepatic sequestration Chapter 8. Bistable Signaling Motifs and Cell Fate Decisions Chapter 9. Ultrasensitive Response Motifs in Biochemical Networks Chapter 10. Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks Chapter 11. Modeling Kidney and Liver Cytotoxicity Chapter 12. Computational Model for Iodide Economy and the HPT Axis in the Adult Rat Chapter 13. Two Stage Clonal Growth Modeling of Cancer Chapter 14. Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures Chapter 15. (Q)SAR Models of Adverse Responses: Acute Systemic Toxicity Chapter 16. Modeling Exposures to Chemicals from Multiple Sources and Routes Chapter 17. Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data Chapter 18. Quantitative Modeling in Noncancer Risk Assessment Chapter 19. Application of Physiologically Based Pharmacokinetic Modeling in Risk Assessment Chapter 20. Uncertainty, Variability and Sensitivity Analyses in Simulation Models Chapter 21. Evaluation of Quantitative Models in Toxicology: Progress and challenges |
Exemplaires (1)
| Cote | Support | Localisation | Section | Disponibilité | Etat_Exemplaire |
|---|---|---|---|---|---|
| 615.9 QUA | Papier | Bibliothèque Centrale | Génie de l'Environnement | Disponible | Consultation sur place |
