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Biopacemaking / Spaan, Jos A. E.

Public ISBD Titre : Biopacemaking Type de document : document électronique Auteurs : Spaan, Jos A. E., Autre ; Coronel, Ruben, Autre ; de Bakker, Jacques M. T., Autre Editeur : Berlin : Springer Année de publication : 2007 Collection : Series in Biomedical Engineering ISBN/ISSN/EAN : 978-3-540-72110-9 Langues : Anglais (eng) Mots-clés : Cardiac  Signals  -  Electrocardiogram  -  IFMBE Résumé : The development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well. This document gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use. Note de contenu : Special issue on biopacemaking: clinically attractive, scientifically a challenge.- Embryological development of pacemaker hierarchy and membrane currents related to the function of the adult sinus node: implications for autonomic modulation of biopacemakers.- Creation of a biological pacemaker by gene- or cellbased approaches.- Creating a cardiac pacemaker by gene therapy.- Biological pacemakers based on If.- Gene therapy to create biological pacemakers.- Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir 2.1 expressing cells.- Propagation of pacemaker activity.- Computer modelling of the sinoatrial node.- Application of mesenchymal stem cell-derived cardiomyocytes as bio-pacemakers: current status and problems to be solved.- Enrichment of cardiac pacemaker-like cells: neuregulin-1 and cyclic AMP increase If-current density and connexin 40 mRNA levels in fetal cardiomyocytes. Biopacemaking [document électronique] / Spaan, Jos A. E., Autre ; Coronel, Ruben, Autre ; de Bakker, Jacques M. T., Autre . - Springer, 2007. - (Series in Biomedical Engineering) . ISBN : 978-3-540-72110-9 Langues : Anglais (eng) Mots-clés : Cardiac  Signals  -  Electrocardiogram  -  IFMBE Résumé : The development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well. This document gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use. Note de contenu : Special issue on biopacemaking: clinically attractive, scientifically a challenge.- Embryological development of pacemaker hierarchy and membrane currents related to the function of the adult sinus node: implications for autonomic modulation of biopacemakers.- Creation of a biological pacemaker by gene- or cellbased approaches.- Creating a cardiac pacemaker by gene therapy.- Biological pacemakers based on If.- Gene therapy to create biological pacemakers.- Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir 2.1 expressing cells.- Propagation of pacemaker activity.- Computer modelling of the sinoatrial node.- Application of mesenchymal stem cell-derived cardiomyocytes as bio-pacemakers: current status and problems to be solved.- Enrichment of cardiac pacemaker-like cells: neuregulin-1 and cyclic AMP increase If-current density and connexin 40 mRNA levels in fetal cardiomyocytes.

Exemplaires

Code-barres	Cote	Support	Localisation	Section	Disponibilité	Etat_Exemplaire
E00228	621.3.038 SPA	Ressources électroniques	Bibliothèque Centrale	Electronique	Disponible
E00227	621.3.038 SPA	Ressources électroniques	Bibliothèque Centrale	Electronique	Disponible