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Computational toxicology / Sean Ekins

Public ISBD Titre : Computational toxicology : risk assessment for pharmaceutical and environmental chemicals Type de document : texte imprimé Auteurs : Sean Ekins, Editeur scientifique Editeur : New York : Wiley Année de publication : 2007 Importance : XXII, 814 p. Présentation : ill. Format : 24 cm ISBN/ISSN/EAN : 978-0-470-04962-4 Note générale : Bibliogr. p.772-775. - Index Langues : Anglais (eng) Mots-clés : Toxicologie  --  Modèles  mathématiques Toxicologie  --  Simulation  par  ordinateur QSAR  (biochimie) Toxicology  --  Mathematical  models Toxicology  --  Computer  simulation QSAR  (Biochemistry) Toxicology  --  Methods Computer  simulation Drug  toxicity Environmental  pollutants  --  Toxicity Risk  assessment Index. décimale : 615.9 Toxicologie en général. Etude des produits toxiques et des poisons. Intoxication Résumé : This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with: *An introduction to toxicology methods and an explanation of computational methods *In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels *Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena *Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development. Note de contenu : Summary of the book: 1. Introduction to toxicology 2. Computational methods 3. Applying computers to toxicology assessment: pharmaceutical 4. Applying computers to toxicology assessment: environmental 5. New technologies for toxicology, future and regulatory perspectives Computational toxicology : risk assessment for pharmaceutical and environmental chemicals [texte imprimé] / Sean Ekins, Editeur scientifique . - New York : Wiley, 2007 . - XXII, 814 p. : ill. ; 24 cm. ISBN : 978-0-470-04962-4 Bibliogr. p.772-775. - Index Langues : Anglais (eng) Mots-clés : Toxicologie  --  Modèles  mathématiques Toxicologie  --  Simulation  par  ordinateur QSAR  (biochimie) Toxicology  --  Mathematical  models Toxicology  --  Computer  simulation QSAR  (Biochemistry) Toxicology  --  Methods Computer  simulation Drug  toxicity Environmental  pollutants  --  Toxicity Risk  assessment Index. décimale : 615.9 Toxicologie en général. Etude des produits toxiques et des poisons. Intoxication Résumé : This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with: *An introduction to toxicology methods and an explanation of computational methods *In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels *Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena *Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development. Note de contenu : Summary of the book: 1. Introduction to toxicology 2. Computational methods 3. Applying computers to toxicology assessment: pharmaceutical 4. Applying computers to toxicology assessment: environmental 5. New technologies for toxicology, future and regulatory perspectives

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Code-barres	Cote	Support	Localisation	Section	Disponibilité	Etat_Exemplaire
054369	615.9 COM	Papier	Bibliothèque Centrale	Génie Chimique	Disponible	Consultation sur place