| Titre : |
Computational toxicology : risk assessment for pharmaceutical and environmental chemicals |
| Type de document : |
texte imprimé |
| Auteurs : |
Sean Ekins, Éditeur scientifique |
| Editeur : |
New York : John Wiley & Sons |
| Année de publication : |
2007 |
| Importance : |
XXII, 814 p. |
| Présentation : |
ill. |
| Format : |
24 cm |
| ISBN/ISSN/EAN : |
978-0-470-04962-4 |
| Note générale : |
Bibliogr. p.772-775. - Index |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Toxicologie -- Modèles mathématiques
Toxicologie -- Simulation par ordinateur
QSAR (biochimie)
Toxicology -- Mathematical models
Toxicology -- Computer simulation
QSAR (Biochemistry)
Toxicology -- Methods
Computer simulation
Drug toxicity
Environmental pollutants -- Toxicity
Risk assessment |
| Index. décimale : |
615.9 Toxicologie en général. Etude des produits toxiques et des poisons. Intoxication |
| Résumé : |
This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with:
*An introduction to toxicology methods and an explanation of computational methods
*In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels
*Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena
*Chapters written by leading international experts
* Figures that illustrate computational models and references for further information
This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development. |
| Note de contenu : |
Summary of the book:
1. Introduction to toxicology
2. Computational methods
3. Applying computers to toxicology assessment: pharmaceutical
4. Applying computers to toxicology assessment: environmental
5. New technologies for toxicology, future and regulatory perspectives |
Computational toxicology : risk assessment for pharmaceutical and environmental chemicals [texte imprimé] / Sean Ekins, Éditeur scientifique . - New York : John Wiley & Sons, 2007 . - XXII, 814 p. : ill. ; 24 cm. ISBN : 978-0-470-04962-4 Bibliogr. p.772-775. - Index Langues : Anglais ( eng)
| Mots-clés : |
Toxicologie -- Modèles mathématiques
Toxicologie -- Simulation par ordinateur
QSAR (biochimie)
Toxicology -- Mathematical models
Toxicology -- Computer simulation
QSAR (Biochemistry)
Toxicology -- Methods
Computer simulation
Drug toxicity
Environmental pollutants -- Toxicity
Risk assessment |
| Index. décimale : |
615.9 Toxicologie en général. Etude des produits toxiques et des poisons. Intoxication |
| Résumé : |
This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with:
*An introduction to toxicology methods and an explanation of computational methods
*In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels
*Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena
*Chapters written by leading international experts
* Figures that illustrate computational models and references for further information
This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development. |
| Note de contenu : |
Summary of the book:
1. Introduction to toxicology
2. Computational methods
3. Applying computers to toxicology assessment: pharmaceutical
4. Applying computers to toxicology assessment: environmental
5. New technologies for toxicology, future and regulatory perspectives |
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