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Post-translational modification of protein biopharmaceuticals / Gary Walsh

Public ISBD Titre : Post-translational modification of protein biopharmaceuticals Type de document : texte imprimé Auteurs : Gary Walsh, Editeur scientifique Editeur : Weinheim : Wiley-vch Verlag Année de publication : 2009 Autre Editeur : Chichester : Wiley-Blackwell Importance : XIX, 370 p. Présentation : ill. Format : 25 cm ISBN/ISSN/EAN : 978-3-527-32074-5 Note générale : Bibliogr. p.353-357. - Index Langues : Anglais (eng) Mots-clés : Protéines  --  Modifications  posttraductionnelles Protéomique Glycosylation Protein  processing,  Post-Translational Biopharmaceutics  --  Methods Biotechnology  --  Methods Protein  engineering  --  Methods Proteins  --  Analysis Index. décimale : 615.3 Médicaments selon leur origine Résumé : From the leading author in the field, known around the world for his work and his authoritative publications, the contents of this book have been selected so as to reflect their relative importance for biopharmaceuticals. As a result, around half of the book is devoted to protein glycosylation, while the remainder is made up of other modifications, such as carboxylation, hydroxylation, sulfation, amidation and proteolytic processing. A final section addresses the latest trend of engineering the modification pattern to improve a given biopharmceutical, presenting several recent case studies of successful posttranslational engineering. This first authoritative overview of the topic is an indispensable guide for drug developers and drug manufacturers with an interest in protein pharmaceuticals. Note de contenu : Au sommaire: 1. Post translational modifications in the context of therapeutic proteins; an introductory overview (Walsh) 2. Protein glycosylation; the basic science (Brookes) 3. Mammalian cell lines and glycosylation; a case study (Butler) 4. Antibody glycosylation (Jefferis) 5. Gonadotropins and the importance of glycosylation (Ulloa-Aguirre) 6. Yeast glycosylation and engineering in the context of therapeutic proteins (Sethuraman) 7. Insect cell glycosylation patterns in the context of biopharmaceuticals (Jarvis) 8. Getting Bacteria to glycosylate (Kowarik, Feldman) 9. Glycoengineering of Erythropoietin (Elliott) 10. Glycoengineering: Cerezyme as a case study (Van Patten, Edmunds) 11. Carboxylation and Hydroxylation (Brown, Stenberg) 12. C-Terminal a-Amidation (Mehta, Carpenter) 13. Disulfide bond formation (Collett) 14. Engineering in a PTM: PEGylation (Bonora, Veronese) Post-translational modification of protein biopharmaceuticals [texte imprimé] / Gary Walsh, Editeur scientifique . - Weinheim : Wiley-vch Verlag : Chichester : Wiley-Blackwell, 2009 . - XIX, 370 p. : ill. ; 25 cm. ISBN : 978-3-527-32074-5 Bibliogr. p.353-357. - Index Langues : Anglais (eng) Mots-clés : Protéines  --  Modifications  posttraductionnelles Protéomique Glycosylation Protein  processing,  Post-Translational Biopharmaceutics  --  Methods Biotechnology  --  Methods Protein  engineering  --  Methods Proteins  --  Analysis Index. décimale : 615.3 Médicaments selon leur origine Résumé : From the leading author in the field, known around the world for his work and his authoritative publications, the contents of this book have been selected so as to reflect their relative importance for biopharmaceuticals. As a result, around half of the book is devoted to protein glycosylation, while the remainder is made up of other modifications, such as carboxylation, hydroxylation, sulfation, amidation and proteolytic processing. A final section addresses the latest trend of engineering the modification pattern to improve a given biopharmceutical, presenting several recent case studies of successful posttranslational engineering. This first authoritative overview of the topic is an indispensable guide for drug developers and drug manufacturers with an interest in protein pharmaceuticals. Note de contenu : Au sommaire: 1. Post translational modifications in the context of therapeutic proteins; an introductory overview (Walsh) 2. Protein glycosylation; the basic science (Brookes) 3. Mammalian cell lines and glycosylation; a case study (Butler) 4. Antibody glycosylation (Jefferis) 5. Gonadotropins and the importance of glycosylation (Ulloa-Aguirre) 6. Yeast glycosylation and engineering in the context of therapeutic proteins (Sethuraman) 7. Insect cell glycosylation patterns in the context of biopharmaceuticals (Jarvis) 8. Getting Bacteria to glycosylate (Kowarik, Feldman) 9. Glycoengineering of Erythropoietin (Elliott) 10. Glycoengineering: Cerezyme as a case study (Van Patten, Edmunds) 11. Carboxylation and Hydroxylation (Brown, Stenberg) 12. C-Terminal a-Amidation (Mehta, Carpenter) 13. Disulfide bond formation (Collett) 14. Engineering in a PTM: PEGylation (Bonora, Veronese)

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Code-barres	Cote	Support	Localisation	Section	Disponibilité	Etat_Exemplaire
054355	615.3 POS	Papier	Bibliothèque Centrale	Biologie	Disponible	Consultation sur place