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The chemical biology of DNA damage / Nicholas E Geacintov

Public ISBD Titre : The chemical biology of DNA damage Type de document : texte imprimé Auteurs : Nicholas E Geacintov, Editeur scientifique ; Suse Broyde, Editeur scientifique Editeur : Weinheim : Wiley-vch Verlag Année de publication : 2010 Importance : XXII, 449 p. Présentation : ill. Format : 25 cm ISBN/ISSN/EAN : 978-3-527-32295-4 Note générale : Bibliogr.p. 429-437. - Index Langues : Anglais (eng) Mots-clés : Altération  de  l'ADN DNA  damage DNA  --  Chemical  biology Index. décimale : 577.213.3 Synthése enzymatique in vitro de l'ADN, de l'ARN. Systèmes de la polymérie de l'ADN, de la réplication de l'ARN. Résumé : Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, part I focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account transcription machineries. A ready reference for bio chemists, toxicologists molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health. Note de contenu : Au sommaire: 1. Introduction and perspectives on the chemistry and biology of DNA damage 2. Chemistry of inflammation and DNA damage: biological impact of reactive nitrogen species 3. Oxidatively generated damage to isolated and cellular DNA 4. Role of free radical reactions in the formation of DNA damage 5. DNA damage caused by endogenously generated products of oxidative stress 6. Polycylic aromatic hydrocarbons: multiple metabolic pathways and the DNA lesions formed The chemical biology of DNA damage [texte imprimé] / Nicholas E Geacintov, Editeur scientifique ; Suse Broyde, Editeur scientifique . - Weinheim : Wiley-vch Verlag, 2010 . - XXII, 449 p. : ill. ; 25 cm. ISBN : 978-3-527-32295-4 Bibliogr.p. 429-437. - Index Langues : Anglais (eng) Mots-clés : Altération  de  l'ADN DNA  damage DNA  --  Chemical  biology Index. décimale : 577.213.3 Synthése enzymatique in vitro de l'ADN, de l'ARN. Systèmes de la polymérie de l'ADN, de la réplication de l'ARN. Résumé : Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, part I focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account transcription machineries. A ready reference for bio chemists, toxicologists molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health. Note de contenu : Au sommaire: 1. Introduction and perspectives on the chemistry and biology of DNA damage 2. Chemistry of inflammation and DNA damage: biological impact of reactive nitrogen species 3. Oxidatively generated damage to isolated and cellular DNA 4. Role of free radical reactions in the formation of DNA damage 5. DNA damage caused by endogenously generated products of oxidative stress 6. Polycylic aromatic hydrocarbons: multiple metabolic pathways and the DNA lesions formed

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Code-barres	Cote	Support	Localisation	Section	Disponibilité	Etat_Exemplaire
054350	577.213.3 CHE	Papier	Bibliothèque Centrale	Biologie	Disponible	Consultation sur place