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Radical and radical ion reactivity in nucleic acid chemistry

Public ISBD Titre : Radical and radical ion reactivity in nucleic acid chemistry Type de document : texte imprimé Auteurs : Greenberg, Marc M., Editeur scientifique Editeur : New York : Wiley Année de publication : 2009 Importance : 458 p. Présentation : ill. Format : 25 cm ISBN/ISSN/EAN : 978-0-470-25558-2 Note générale : index Langues : Anglais (eng) Mots-clés : Acides  nucléiques  --  Effets  des  rayonnements Ionisation Radicaux  libres  (chimie) Index. décimale : 577.323 Physique et physico-chimie des acides nucléiques Résumé : Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective. The chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates. With contributions by world leaders in the field, the text covers a broad range of topics, including: * A discussion of the relevant theory * Ionization of DNA * Nucleic acid sugar radicals * Halopyrimidines * Oxidative, reductive, and low energy electron transfer * Electron affinity sensitizers * Photochemical generative of reactive oxygen species * Reactive nitrogen species * Enediyne rearrangements * Phenoxyl radicals A unique compilation on the cutting edge of our understanding, Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines. Note de contenu : In summary : 1. Theoretical Modeling of Radiation-Induced DNA Damage 1 Anil Kumar and Michael D. Sevilla 2. Radical Reaction Pathways Initiated by Direct Energy Deposition in DNA by Ionizing Radiation 41 William A. Bernhard 3. Chemical Reactions of the Radical Cations of Nucleobases in Isolated and Cellular DNA. Formation of Single-Base Lesions 69 Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat, and J. richard Wagner 4. Reactivity of Nucleic Acid Sugar Radicals 99 Chryssostomos Chatgilialoglu 5. Pyrimidine Nucleobase Radical Reactivity 135 Marc M. Greenberg 6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163 Ryu Tashiro and Hiroshi Sugiyama 7. Kinetics of Long-Range Oxidative Electron Transfer Through DNA 191 Kiyohiko Kawai and Tetsuro Majima 8. Radical Intermediates During Reductive Electron Transfer Through DNA 211 Reji Varghese and Hans-Achim Wagenknecht 9. Low-Energy Electron Interaction with DNA: Bond Dissociation and Formation of Transient Anions, Radicals, and Radical Anions 239 Leon Sanche 10. Electronic-Affinic Radiosensitizers 295 Peter Wardman 11. Reactions of Reactive Nitrogen Species and Carbonate Radical Anions with DNA 325 Vladimir Shafirovich, Conor Crean, and Nicholas E. Geacintov Radical and radical ion reactivity in nucleic acid chemistry [texte imprimé] / Greenberg, Marc M., Editeur scientifique . - New York : Wiley, 2009 . - 458 p. : ill. ; 25 cm. ISBN : 978-0-470-25558-2 index Langues : Anglais (eng) Mots-clés : Acides  nucléiques  --  Effets  des  rayonnements Ionisation Radicaux  libres  (chimie) Index. décimale : 577.323 Physique et physico-chimie des acides nucléiques Résumé : Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective. The chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates. With contributions by world leaders in the field, the text covers a broad range of topics, including: * A discussion of the relevant theory * Ionization of DNA * Nucleic acid sugar radicals * Halopyrimidines * Oxidative, reductive, and low energy electron transfer * Electron affinity sensitizers * Photochemical generative of reactive oxygen species * Reactive nitrogen species * Enediyne rearrangements * Phenoxyl radicals A unique compilation on the cutting edge of our understanding, Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines. Note de contenu : In summary : 1. Theoretical Modeling of Radiation-Induced DNA Damage 1 Anil Kumar and Michael D. Sevilla 2. Radical Reaction Pathways Initiated by Direct Energy Deposition in DNA by Ionizing Radiation 41 William A. Bernhard 3. Chemical Reactions of the Radical Cations of Nucleobases in Isolated and Cellular DNA. Formation of Single-Base Lesions 69 Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat, and J. richard Wagner 4. Reactivity of Nucleic Acid Sugar Radicals 99 Chryssostomos Chatgilialoglu 5. Pyrimidine Nucleobase Radical Reactivity 135 Marc M. Greenberg 6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163 Ryu Tashiro and Hiroshi Sugiyama 7. Kinetics of Long-Range Oxidative Electron Transfer Through DNA 191 Kiyohiko Kawai and Tetsuro Majima 8. Radical Intermediates During Reductive Electron Transfer Through DNA 211 Reji Varghese and Hans-Achim Wagenknecht 9. Low-Energy Electron Interaction with DNA: Bond Dissociation and Formation of Transient Anions, Radicals, and Radical Anions 239 Leon Sanche 10. Electronic-Affinic Radiosensitizers 295 Peter Wardman 11. Reactions of Reactive Nitrogen Species and Carbonate Radical Anions with DNA 325 Vladimir Shafirovich, Conor Crean, and Nicholas E. Geacintov

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053752	577.323 RAD	Papier	Bibliothèque Centrale	Biologie	Disponible	Consultation sur place