| Titre : | Metallopharmaceuticals I : DNA interactions |
| Auteurs : | Clarke , M. J., Éditeur scientifique ; Sadler , P. J., Éditeur scientifique |
| Type de document : | texte imprimé |
| Editeur : | Berlin ; London ; New York : Springer, 1999 |
| Collection : | Topics in biological inorganic chemistry, ISSN 1437-7993, num. Vol. 1 |
| ISBN/ISSN/EAN : | 978-3-540-64889-5 |
| Format : | 199 p. / ill. / 24 cm |
| Langues : | Anglais |
| Index. décimale : | 577.1 (Bases chimiques de la vie. Biochimie et chimie bioorganique en général) |
| Tags : | Chimie inorganique Médicaments Platine -- Composés -- Emploi en thérapeutique Ruthénium -- Composés -- Emploi en thérapeutique ADN Cancer -- Chimiothérapie |
| Résumé : |
Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonance imaging (e.g.GD)demonstrates that the toxicity of metals can be finaly controlled via the appropriate choice of ligands. The successful trageting of radiosotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics. |
| Note de contenu : |
Contents:
- Anticancer activity of cisplatin and related complexes. - Development of an orally active platinum anticancer drug: JM216. - Trans-platinum compounds in cancr therapy. - Chemistry and biology of multifunctional DNA binding agents. - Role of metal ions in antisense and antigene stategies. - Sulfoxide ruthenium complexes. - Non-platinum antitumor compounds. |
Exemplaires (2)
| Cote | Support | Localisation | Section | Disponibilité | Etat_Exemplaire |
|---|---|---|---|---|---|
| 577.1 MET | Papier | Bibliothèque Centrale | Génie Chimique | Disponible | En bon état |
| 577.1 MET | Papier | Bibliothèque Centrale | Génie Chimique | Disponible | En bon état |
